Endocrine Abstracts

Variants of ADIPOQ have been inconsistently associated with adiponectin level in diverse populations. We explored association of single nucleotide polymorphism (SNP) in the ADIPOQ (+276 G>T, rs1501299) with circulating total adiponectin and insulin resistance (IR) in Ukrainian T2DM cohort.Materials and methods: 544 T2DM patients (M/F: 241/303, age 56.3±0.4 years, diabetes duration 7.8±1.0 years, BMI 31.7&...

Introduction: The objective is to evaluate the relationship between early blood pressure alterations (detected by ambulatory blood pressure monitoring (abpm)) and the development/progression of retinopathy in patients with type 1 diabetes clinically normotensive.Methods: We designed a prospective observational study of 85 patients, clinically normotensive and without microalbuminuria, monitored over 7 years. Abpm was performed over 24 h and subclinical h...

Introduction: The objective is to evaluate the relationship between early blood pressure alterations (detected by ambulatory blood pressure monitoring (abpm)) and the development of microalbuminuria and arterial hypertension in patients with type 1 diabetes clinically normotensive.Methods: We designed a prospective observational study of 85 patients, clinically normotensive and without microalbuminuria, monitored over 7 years. Abpm was performed over 24 ...

Introduction: The objective is to evaluate the relationship between precocious subclinical hypertension and inflammatory and endothelial dysfunction markers in normotensive and normoalbuminuric patients with type 1 diabetes.Methods: We designed an observational transversal study of 85 patients, clinically normotensive and without microalbuminuria. Ambulatory blood pressure monitoring (abpm) was performed over 24 h and subclinical hypertension was conside...

Objectives: To evaluate the prevalence of blood pressure alterations by ABPM and its association with clinical factors in normotensive and normoalbuminuric patients with type 1 diabetes (TDM1).Methods: Cross-sectional study including normotensive and normoalbuminuric patients with TDM1. Altered ABPM was considered when: i) Mean systolic pressure (sBP) was ≥130 mmHg in the 24 h and daytime periods and ≥120 mmHg in the night-time period and/or ...

Objectives: To evaluate the validity as diagnostic test of isolated blood pressure measurement compared to 24 h ambulatory blood pressure monitoring (ABPM) in a group of clinically normotensive patients with type 1 diabetes (TDM1).Methods: Cross-sectional study including 85 normotensive and normoalbuminuric patients with TDM1. Media of two blood pressure measures by conventional technique and results of the 24 h blood pressure monitoring (SPACELABS 90217...

Objective: To evaluate changes of ambulatory blood pressure monitoring (ABPM) parameters in normotensive and normoalbuminuric patients with type 1 diabetes (TDM1) after 7 years.Methods: A longitudinal study conducted in normotensive and normoalbuminuric patients with TDM1. ABPM (Spacelabs 90217) basal was performed. Altered ABPM was considered when: i) Mean systolic pressure (sBP) was ≥130 mmHg in the 24 h and daytime periods and ≥120 mmHg in...

Introduction: Endocrine Society guideline indications for screening (EGS) of hypertensive patients for hyperaldosteronism are not universally followed in clinical Endocrinology. We present a series of patients with hyperaldosteronism, diagnosed following strict EGS compliance.Methods: Retrospective. Following compliance with EGS in all patients attended in a general Endocrinology outpatient clinic, 70 hypertensive patients were diagnosed with hyperaldost...

Objective: To investigate factors associated with the presence and growth rate of thyroid nodules(TN) in patients with acromegaly.Methods: We retrospectively evaluated the medical records of 52 patients with acromegaly followed in our institution (University Hospital Ramón y Cajal). The frequencies of TN and papillary thyroid cancer (PTC) and potential factors associated with nodular thyroid disease (NTD) were investigated. In patients with NTD (<em...

Introduction: The insulin tolerance test (ITT) is the gold standard method to assess GH and/or ACTH deficiency. Safety concerns with the use of this test were raised more than 20 years ago from overtreatment of hypoglycaemia and consequent cerebral oedema, resulting in some centres using alternative tests. We have re-appraised use of the ITT in a contemporary setting and evaluated: i) timing of the glucose nadir, ii) time to resolution of hypoglycaemia, iii) adverse events and...